PUBLICACIONES ANTERIORES

De un total de 189 publicaciones, destacamos 127 artículos en revistas de impacto hasta 2010

  1. B. Maccioni and N.W. Seeds (1977) “Stoichiometry of GTP hydrolysis and tubulin polymerization”. Proc. Natl. Acad. Sci. U.S.A 74: 462-468

    2.  

  2. L. Dinamarca, A. Ramirez, E. Ballester, J. Capdevila and R.B. Maccioni (1975) “DDT dehydrochlorinase. Further evidences on the lipoprotein nature of the enzyme.” International J. Biochemistry 6: 405-412

    3.  

  3. B. Maccioni and N.W. Seeds (1978) “Enhancement of tubulin assembly as monitored by a rapid filtration assay”. Arch. Biochem. Biophys. 185: 262-272

    4.  

  4. W. Seeds and R.B. Maccioni (1978) “Proteins from morphologically differentiated neuroblastoma cells promoting tubulin polymerization”. J. Cell Biology 76: 547-556

    5.  

  5. B. Maccioni, E. Hubert and J.C. Slebe (1979) “Selective modifications of Fructose-1,6-bisphosphatase by periodate-oxidized AMP”. FEBS Lett. 102: 29-32.

    6.  

  6. Hubert, R.B. Maccioni and J.C. Slebe (1979) “Isolation and characterization of the AMP binding site on fructose-1,6-bisphosphatase”. Arch. Biol. Med. Exper. 12: 272-275

    7.  

  7. Mellado, J.C. Slebe and R.B. Maccioni (1980) “Tubulin carbamoylation and inhibition of the microtubule assembly”. Biochem. Int. 1: 584-590

    8.  

  8. B. Maccioni, W. Mellado and J.C. Slebe (1980) “Carbamilación de tubulina y su efecto en la formación de microtúbulos”. Arch. Biol. Med. Exper. 13: 466-467

    9.  

  9. B. Maccioni and J. Babul (1980) “Purification and characterization of glucokinase”. Arch. Biol. Med. Exper. 13: 271-286

    10.  

  10. Hubert, R.B. Maccioni and J.C. Slebe (1981) “Affinity labeling of fructose-1,6-bisphosphatase with adenosine 5´-monophosphate 2´,3´-dialdehyde”. Arch. Biol. Med. Exper. 14: 157-161

    11.  

  11. B. Maccioni, J.C. Vera and J. C. Slebe (1981) “Arginyl residues involvement in the microtubule assembly”. Arch. Biochem. Biophys. 207: 248-255

    12.  

  12. B. Maccioni and W. Mellado (1981) “Characteristics of the in vitro assembly of tubulin from brain of Cyprinus carpio“. Comparative Biochemistry and Physiology 70B: 375-380

    13.  

  13. Mellado, J.C. Slebe and R.B. Maccioni (1982) “Tubulin carbamoylation: Role of amino residues in microtubule assembly”. Biochem. J. 203: 675-681

    14.  

  14. B. Maccioni and N.W. Seeds (1981) “Inhibition of tubulin assembly by limited proteolysis and protection by GTP”. J. Cell Biol. 91: 322-324

    15.  

  15. B. Maccioni and N.W. Seeds (1982) “Residual nucleotide and tubulin´s ability to polymerize with nucleotide analogs”. J. Biol. Chem. 257: 3334-3338

    16.  

  16. B. Maccioni and N.W. Seeds (1982) “Involvement of tryptophan residues in colchicine binding and the assembly of tubulin”. Biochem. Biophys. Res. Commun. U.S.A. 108: 896-903

    17.  

  17. B. Maccioni (1983) “Microtubule assembly affected by the presence of denatured tubulin”. Biochem. Biophys. Res. Commun. 110: 463-469

    18.  

  18. B. Maccioni and N.W. Seeds (1983) “Affinity labeling of tubulin´s exchangeable GTP binding site”. Biochemistry   22: 1567-1572

    19.  

  19. B. Maccioni and N.W. Seeds (1983) “Limited proteolysis of tubulin: Nucleotide stabilizes an active conformation”. Biochemistry 22: 1572-1578

    20.  

  20. Serrano, J.C. Diez, J. Avila and R.B. Maccioni (1983) “Controlled proteolysis of tubulin with subtilisin: Structural changes and functional consequences”. J. Submicrosc. Cytol. 16: 55-56

    21.  

  21. Serrano, J. Avila and R.B. Maccioni (1984) “Controlled proteolysis of tubulin by subtilisin: Localization of the site for MAP-2 interaction”. Biochemistry 23: 4675-4681

    22.  

  22. Serrano, J. de la Torre, R.B. Maccioni and J. Avila (1984) “Involvement of the carboxyl-terminal domain of tubulin in the regulation of its assembly”. Proc. Natl. Acad. Sci. U.S.A. 81: 5989-5993

    23.  

  23. Serrano, J. Avila and R.B. Maccioni (1984) “Limited proteolysis of tubulin and the localization of the binding site for colchicine”. J. Biol. Chem. 259: 6607-6611.

    24.  

  24. Slebe, R. Herrera, E. Hubert, A. Ojeda and R.B. Maccioni (1984) “Fructose-1,6-bisphosphatase: Dissociation of AMP cooperativity and the AMP inhibition by carbamoylation”. J. Protein Chem. 2: 437-443

    25.  

  25. B. Maccioni, L. Serrano and J. Avila (1985) “Structural and functional domains of tubulin”. BioEssays 2: 165-169 (Review)

    26.  

  26. B. Maccioni and N.W. Seeds (1986) “Transglutaminases in neuronal differentiation”. Mol. Cell. Biochem. 69: 161-168

    27.  

  27. B. Maccioni, L. Serrano, J. Avila and J.R. Cann (1986) “Characterization and structural aspects of the enhanced assembling capacity of tubulin after removal of its carboxyl-terminal domain”. Eur. J. Biochem. 156: 375-381

    28.  

  28. B. Maccioni, J.R. Cann and J. Stewart (1986) “Interaction of tubulin with substance P”. Eur. J. Biochem. 154: 427-435

    29.  

  29. Avila, L. Serrano and R.B. Maccioni (1987) “Regulatory aspects of the colchicine interaction with tubulin”. Mol. Cell Biochem. 73: 29-36

    30.  

  30. B. Maccioni and J. Arechaga (1986) “Transglutaminase involvement in early embryogenesis”. Expertl. Cell Res. 167: 266-270

    31.  

  31. Sigiura, R.B. Maccioni, J. Cann, E. York, J. Stewart and G. Kotovych (1987) “A proton magnetic resonance and a circular dichroism study of the solvent-dependent conformation of the synthetic tubulin fragment Ac-Tubulin, alpha (430-441) amide and its interaction with substance P”. J. Biomol. Struct. and Dynamics 4: 1105-1117

    32.  

  32. C. Vera, C. Rivas, and R.B. Maccioni (1988) “Antibodies to synthetic peptides from tubulin´s regulatory domain interact with tubulin and microtubules”. Proc. Natl. Acad. Sci. USA 85: 6763-6767
  33. C. Vera, C. Rivas and R.B. Maccioni (1988) “Heat stable microtubule- associated proteins binds to microtubules and induces microtubule asembly”. FEBS Letters 232: 159-162

    34.  

  34. B. Maccioni, J. C.Vera and C. Rivas, (1988) “Differential interactions of synthetic peptides from the carboxyl-terminal regulatory domain of tubulin with MAPs”. The EMBO Journal 7: 1957-1963

    35.  

  35. I. Rivas, J. C. Vera and R.B. Maccioni (1988) “Anti-idiotypic antibodies that react with MAPs are present in the sera of rabbits immunized with synthetic peptides from tubulin´s regulatory domain”. Proc. Natl. Acad. Sci. U.S.A . 85: 6092-6096

    36.  

  36. Cann, E. York, J. Stewart, J.C. Vera and R.B. Maccioni (1988) “Small zone gel chromatography of interacting systems: theoretical and experimental evaluation of elution profiles for kinetically controlled macromolecule-ligand reactions”. Anal. Biochemistry 175: 462-473

    37.  

  37. B. Maccioni (1988) Invited book review: “The Cytoskeleton” (A. Bershadsky and A. Vasiliev, eds). FASEB Journal 6: 21

    38.  

  38. B. Maccioni, J.C. Vera, J. Dominguez and J. Avila (1989) “A discrete repeated sequence defines a tubulin binding domain on tau”. Archives Biochemistry and Biophysics 275: 568-579.

    39.  

  39. C. Vera, C.I. Rivas, and R.B. Maccioni (1989) “Biochemical dissection of the role of the 1 kDa C-terminal domain of tubulin subunits in the assembly of microtubules”. Biochemistry   28: 333-339

    40.  

  40. Padilla, R.B. Maccioni and J. Avila (1990) “Calmodulin binds to the tubulin binding domain on tau protein”. Molecular and Cellular Biochemistry 97: 35-42

    41.  

  41. Rivas-Berrios, M.A. Hernández, J. Dominguez, J. Avila and R.B. Maccioni (1990) “Common structural features of the tubulin binding domain on microtubule-associated proteins MAP-2 and tau”. Biochimica et Biophysica Acta   1040: 382-390

    42.  

  42. Otter, R.B. Maccioni and G. Kotovych (1991) “The solution conformation of tubulin beta-(422-434) peptide and its Nac-DATADEQG-NH2 fragment based on NMR”. Biopolymers 31:449-458

    43.  

  43. Cross, J. Dominguez, R.B. Maccioni and J. Avila (1991) “MAP-1 and MAP-2 binding sites at the C-terminus of Beta Tubulin. Studies using synthetic tubulin peptides”. Biochemistry   30: 4362-4367

    44.  

  44. Farías, C. Vial and R.B. Maccioni (1992) “Specific macromolecular interactions between tau and the microtubule system”. Molecular and Cellular Biochemistry 112: 81-88

    45.  

  45. Moraga, A. Rivas, G. Farías, M. Wallin and R.B. Maccioni (1992) “Estramustine-phosphate binds to a tubulin domain on microtubule-associated proteins MAP-2 and tau”. Biochimica et Biophysica Acta 1121:97-103

    46.  

  46. Martínez, F. Santibañez, C. Vial and R.B. Maccioni (1992) “The antineoplasic drug estramustine-and the derivative.estramustine-phosphate inhibit secretion of interleukin-3 in cultured leukemic cells: Possible roles of MAPs”. Molecular and Cellular Biochemistry 117: 165-173

    47.  

  47. Farias, C. Vial and R.B. Maccioni (1993) “Functional epitopes on chemically modified tau protein”. Cellular and Molecular Neurobiology 13: 173-182.

    48.  

  48. Cross, C. Vial and R.B. Maccioni (1993) ” A tau like protein interacts with stress fibers and microtubules in human and rodent cultured cell lines”. Journal of Cell Science 105: 51-60

    49.  

  49. Moraga, P. Nuñez, J. Garrido and R.B. Maccioni (1993) “A tau fragment containing a repetitive sequence induces bundling of actin filaments”. Journal of Neurochem. 61: 979-987

    50.  

  50. Guzmán, R. Bustos and R.B. Maccioni (1994) “Purification and characterization of the high molecular weight microtubule-associated proteins from neonatal rat brain”. Molecular and Cellular Biochemistry 131: 105-113

    51.  

  51. Cross, G. Farías, J. Dominguez, J. Avila and R.B. Maccioni (1994) ” Carboxyl-terminal sequences of beta-tubulin involved in the interaction of HMW-MAPs. Studies using site-specific antibodies”. Molecular and Cellular Biochemistry 132: 81-90

    52.  

  52. B. Maccioni (1994) “Nuevas proteínas que regulan los patrones de interacción entre elementos de la citoarquitectura y estructuras celulares”. Notic. Biol. 2: 18-19.

    53.  

  53. Cambiazo, M. González, and R.B. Maccioni (1995) “DMAP: a tau-like novel protein from Drosophila melanogaster larvae“. Journal of Neurochemistry 64: 1288-1297

    54.  

  54. González, V. Cambiazo and R.B. Maccioni (1995) “Identification of a new microtubule interacting protein Mip-90”. European Journal of Cell Biology   67: 158-169

    55.  

  55. Vial, R. Armas-Portela, J. Avila, M. González and R.B. Maccioni (1995) “A 205 kDa protein from non-neuronal cells in culture contains tubulin binding epitopes” Molecular and Cellular Biochemistry 144: 109-116

    56.  

  56. Farias, M. González, and R.B. Maccioni (1995) “Tubulin and Microtubule-associated protein pools in unfertilized and fertilized eggs of the trout Oncorhynchus mykiss”. Journal of Experimental Zoology 271: 253-263

    57.  

  57. Santibañez, R.B. Maccioni, and J. Martínez (1995) “The secretion of urokinase-like plasminogen activator is inhibited by microtubule-interacting drugs”. Cell Biochemistry and Function 13: 217-225.

    58.  

  58. B. Maccioni, and P. Rodrigues (1995) “Alzheimer´s disease: an approach to molecular medicine”. (Review article) Ciencia Hoje 20: 34-39

    59.  

  59. B. Maccioni, L. Tapia and V. Cambiazo (1995) “Functional organization of Tau proteins during neuronal differentiation and development” (Review). Brazilian J. Med. and Biol. Research v.28: 827-841

    60.  

  60. P. Henríquez, D. Cross, C. Vial and R.B. Maccioni (1995) “Subpopulations of tau interact with microtubules and actin filaments in different cell types”. Cell Biochemistry and Function 13: 239-250

    61.  

  61. B. Maccioni and V. Cambiazo (1995) “The roles of Microtubule-associated proteins in the control of microtubule assembly”. (Review article) Physiological Reviews v.75: 835-864 (i.f.= 35.86)

    62.  

  62. P. Henriquez, V. Cambiazo, and R.B. Maccioni (1996) “Tubulin domains for the interaction of microtubule-associated protein DMAP-85 from Drosophila melanogaster“. Molecular and Cellular Biochemistry 158: 149-159

    63.  

  63. Cross, L. Tapia, J. Garrido and R.B. Maccioni (1996) “Tau-like proteins associated with centrosomes in cultured cells”. Experimental Cell Research 229: 378-388

    64.  

  64. Farias, C. González and R.B. Maccioni (1997) “Immunological characterization of epitopes on tau of Alzheimer´s type and chemically modified tau protein”. Molecular and Cellular Biochemistry 168: 59-67

    65.  

  65. Gonzalez, Cambiazo, V., and R.B. Maccioni (1998) “The interactions of Mip-90 with microtubules and actin filaments in human fibroblasts”. Experimental Cell Research 239: 243-253

    66.  

  66. Capote, C. and R.B. Maccioni (1998) “The association of tau-like proteins with vimentin filaments in cultured cells”. Experimental Cell Research 239: 202-213

    67.  

  67. Paglini, G. Pigino, P. Kunda, G. Morfini, R.B. Maccioni, S. Quiroga, A. Ferreira and A. Cáceres (1998) “Evidence for the participation of the neuron-specific cdk5 activator, P35, during laminin-enhanced axonal growth”. Journal of Neurosciences 18: 9858- 9869

    68.  

  68. González-Billault, G. Farías and R.B. Maccioni (1998) “Glycation of tau to an Alzheimer´s type protein interferes with its interaction with microtubules”. Cellular and Molecular Biology 44: 1117- 1127

    69.  

  69. Capote, C. and R.B. Maccioni (1998) “The association of tau-like proteins with vimentin filaments in cultured cells”. Experimental Cell Research 239: 202-213

    70.  

  70. Depix, J. Martínez, F. Santibañez, J. Rovirosa, A. San Martín and R.B. Maccioni (1998) “The compound 14-keto-stypodiol diacetate from the algae Stypopodium flabelliforme inhibits microtubules and cell proliferation in DU-145 human prostatic cancer cells”. Molecular and Cellular Biochemistry 187: 191-199

    71.  

  71. González-Billault, G. Farías and R.B. Maccioni (1998) “Modification of tau to an Alzheimer´s type protein interferes with its interaction with microtubules”. Cellular and Molecular Biology (Noisy-le-Grand) 44: 1117- 1127

    72.  

  72. Ramirez, A. Alvarez, J. García-Abreu, F. Gomes, V. Moura-Neto and R.B. Maccioni (1999) “Regulatory roles of tau in neuronal morphogenesis. Involvement of the extracellular matrix”. Braz. J. Med. Biol. Res. 32: 611-618

    73.  

  73. Cambiazo, M. González, C. Isamit and R.B. Maccioni (1999) “The beta-isoform of the heat-shock protein hsp-90 is structurally related with human microtubule-interacting protein Mip-90”. FEBS Lett. 457:343-347

    74.  

  74. Alvarez, R. Toro, A. Cáceres and R.B. Maccioni (1999) “Inhibition of tau phosphorylating kinase cdk-5 by butyrolactone and tau antisense probes prevents amyloid-induced neuronal death”. FEBS Lett . 459: 421-426

    75.  

  75. Saragoni, L., Hernández, P. and Maccioni, R.B. (2000) “Diferential association of tau with subsets of microtubules containing postraslationally modified tubulin variants in neuroblastoma cells”. Neurochemical Research 25 (1): 59-70

    76.  

  76. Cross, D., Muñoz, JP, Hernández, P. and Maccioni, R.B. (2000) “Nuclear and cytoplasmic tau proteins from human non-neuronal cells share common structural and functional features with brain tau”. Journal Cellular Biochemistry 78: 305-317

    77.  

  77. P. Muñoz, A. Alvarez, and R.B. Maccioni (2000) “Increase in the expression of the cyclin-dependent protein kinase cdk5 during differentiation of neuroblastoma cells” NeuroReport 11: 2733-2738

    78.  

  78. B. Maccioni, C. Otths, I. Concha and J.P. Muñoz, (2001) “The protein kinase Cdk5: structural aspects, roles in neurogenesis and involvement in Alzheimer´s pathology”. European J. Biochemistry. v. 268: 1518- 1529 (Review by invitation)

    79.  

  79. B. Maccioni, L. Barbeito and J.P. Muñoz (2001) The molecular bases of Alzheimer´s disease and other neurodegenerative disorders”. Arch. Medical Research 32: 367-381 (paper with a high citation index)

    80.  

  80. Cambiazo, M. González and R.B. Maccioni (2001) “Expression patterns of DMAP85 during Drosophila embryonic development”. Mechanisms of Development 108: 197-201

    81.  

  81. B. Maccioni (2001) “Cdk5: minireview series”. European J. Biochemistry 268: 1517-1518

    82.  

  82. Alvarez, J.P. Muñoz, and R.B. Maccioni (2001) “A cdk5/p35 stable complex is involved in the beta-amyloid induced deregulation of Cdk5 activity in hippocampal neurons”. Experimental Cell Research 264: 266-275

    83.  

  83. Farias, J.P. Muñoz, J. Garrido and R.B. Maccioni (2002) “Tubulin, actin and tau protein interactions and the study of their macromolecular assemblies”. J. Cellular Biochemistry 85: 315-324

    84.  

  84. Otth, I. Concha, T. Arendt, J Stieler, R. Schlieb, C. González-Billault and R.B. Maccioni (2002) “Expression of human APP in the transgenic mice model TG2576 reproduce deregulation of Cdk5 in the pathway to neurodegeneration”. J. Alzheimer´s Disease 4: 417-331

    85.  

  85. Nuñez, V. Tapia, P. Muñoz, R.B. Maccioni and M.T. Núñez (2002) “An oxidative stress-mediated positive feedback iron uptake loop in neuronal cells”. Journal Neurochemistry 82: 240-248

    86.  

  86. B. Maccioni (2002). “Opinion on the journal”. Arch. Med. Res. 33: 512

    87.  

  87. T. Nuñez, C. Nuñez, V. Tapia, P. Muñoz, D. Mazariegos, M. Arredondo, C. Mura and R.B. Maccioni (2003) “Iron activated iron uptake: a positive feedback loop mediated by iron regulatory protein”. BioMetals 16: 83-90

    88.  

  88. T. Egaña, C. Zambrano, M.T. Nuñez, C.González-Billault and R.B. Maccioni (2003) “Iron-induced oxidative stress modify tau phosphorylation patterns in hippocampal cells in culture”. BioMetals 16: 215-224

    89.  

  89. P. Muñoz, J. Sánchez and R.B. Maccioni (2003) “Regulation of p27 protein in the process of neuroblastoma differentiation”. J. Cell Biochem 89: 539-549

    90.  

  90. Otth, A. Mendoza-Naranjo, L. Mujica, A. Zambrano, I. I. Concha and R. B. Maccioni (2003) “Modulation of the JNK and p38 Pathways by Cdk5 Protein Kinase in a Transgenic Mouse Model of Alzheimer’s Disease” NeuroReport 14: 2403-2409

    91.  

  91. Maccioni, M. Arzola, L. Mujica and R.B. Maccioni (2003) “New paradigms in the study of patogénesis of Alzheimer´s disease”. Rev. Chil. Neuro Psiquiat 41: 33-46

    92.  

  92. R.B. Maccioni, J.P. Muñoz and C.B. Maccioni (2003) “Dimensiones bioéticas de la   investigación sobre el genoma humano”. Acta Bioética 10: 75-81

    93.  

  93. Zapata, F. Opazo, C. Salgado, J.P. Muñoz, H. Krauswurst, C. Mascayano, S. Sepúlveda, R.B. Maccioni and B. Cassels (2004) “Effects of natural flavones and flavon-3-ols on kinase activity of cdk5”. J. Nat. Products 67: 416-420

    94.  

  94. C. A. Zambrano, J. T. Egaña, M. T. Núñez, R. B. Maccioni and C. González-Billault (2004) “Oxidative stress promotes tau dephosphorylation in neuronal cells: the roles of Cdk5 and PP1”. Free Rad. Res. Med. 36: 1393-1402

    95.  

  95. Quintanilla, D. Orellana, C. Gonzalez-Billault, and R.B. Maccioni (2004) “Interleukin-6 induces Alzheimer´s phosphorylation of tau protein by deregulating the cdk5/p35 pathway”. Exp. Cell Res. 295: 245-257

    96.  

  96. B. Maccioni, M. Lavados, C.B. Maccioni and A. Mendoza (2004) “Biological markers of Alzheimer´s disease and mild cognitive impairment”. Current Alzheimer Research 1: 307-314

    97.  

  97. E.T. Saez, M. Pehar, L. Barbeito and R.B. Maccioni (2004) Astrocytic nitric oxide triggers tau hyperphosphorylation in hippocampal neurons. In VIVO 18: 275-280 98.

    98.  

  98. Q Liu, M A Smith, S L Siedlak, P L Harris, R B Maccioni, L M Sayre and G Perry (2004) “Phosphorylation-modulated oxidative stress modification of neurofilament protein”. Journal of Neuropathology & Experimental Neurology. 63(5):523 99.

    99.  

  99. M. Lavados, G. Farias, F. Rothhammer, M. Guillón, C.B. Maccioni and R.B. Maccioni (2005) “ApoE alleles and tau markers in patienets with different levels of cognitive impairment”. Arch. Med. Res. 36: 474-479.

    100.  

  100. D.I. Orellana, RA Quintanilla, C. Gonzalez and R.B. Maccioni (2005) Role of JAKs/STAT pathway in the intracellular calcium changes induced by interleukin-6 in hippocampal neurons. Neurotoxicity Res 8: 295-304

    101.  

  101. R.B. Maccioni, M. Lavados, CB Maccioni, G. Farias and P. Fuentes (2006) “Anomalously phosphorylated tau protein and Abeta fragments in the CSF icorrelates with cognitive impairment in MCI subjects”. Neurobiol Aging 27: 237-244

    102.  

  102. P. Muñoz, C. Huichalaf, D. Orellana and R.B. Maccioni (2007) Cdk5 modulates b and d-catenin/Pin1 interactions in neuronal cells. J. Cell Biochem. 100: 738-749

    103.  

  103. Sjoberg, ME. Shestakowa, Z. Mansoroglu, R.B. Maccioni and E. Bonnefoy (2006) Tau protein binds perocentromeric DNA: A putative role for nuclear tau in nucleolar organization. J. Cell Sci. 119: 2025-2034

    104.  

  104. Rojo, Sjoberg, M., Hernandez, P., Zambrano, C., and Maccioni RB (2006) Roles of cholesterol and lipids in the etiopathogenesis of Alzheimer´s disease. J. Biomedicine and Biotech. (special issue on Alzheimer´s Disease) vol. 2006 (3): 73976 p 1- 17

    105.  

  105. Sáez, M. Pehar, M. Vargas, L. Barbeito and R.B. Maccioni (2006) Production of NGF by beta-amyloid-stimulated astrocytes induces p75NTR-dependent tau hyperphosphorylation in cultured hyppocampal neurons. J. Neurosci. Res. 84: 1098-1106.

    106.  

  106. Orellana, R. Quintanilla, and R.B. Maccioni (2007) Neuroprotective effect of TNFalpha against the beta-amyloid neurotoxicity mediated by CDK5 kinase. Biochim Biophys Acta. 1773: 254-263. Oct 21. This paper is the basis for the TNFalpha novel anti-inflammatory molecules (etanercept) that have recently reported in Alzheimer´s treatment.

    107.  

  107. Mendoza, C. Gonzalez, and R.B. Maccioni (2007) Abeta1-42 stimulates actin polymerization in hippocampal neurons through Rac1 and Cdc42 Rho GTPases. J Cell Sci.;120:279-288. Epub 2007 Jan 20.

    108.  

  108. Zambrano, C. Otth, L. Mujica, I. Concha and R.B. Maccioni (2008) “Interleukin-3 prevents neuronal death induced by amyloid peptide”. BMC Neuroscience 8: 82-85.

    109.  

  109. Utreras, Jimenez-Mateos EM, Contreras-Vallejos E, Tortosa E., Perez M, Rojas S, Saragoni L,Maccioni RB, Avila J, Gonzalez C(2008) “Microtubule-associated protein 1B interaction with tubulin tyrosine ligase contributes to the control of microtubule tyrosination”. Developmental Neuroscience 30 (1-3): 200-210

    110.  

  110. Rojo, J. Fernández, A. A. Maccioni, J. Jimenez and R.B. Maccioni (2008) “Neuro-inflammation: implications for pathogenesis and molecular diagnosis of Alzheimer´s disease”. Arch. Med. Res. 39. 1-16 E pub Oct 31

    111.  

  111. Lavados, M. Guillón, C. Mujica, L.E. Rojo, P.Fuentes, R.B. Maccioni (2008). “Mild Cognitive Impairment and Alzheimer patients display different levels of Redox-active CSF Iron”. J. Alz. Dis. 13, number 2, 225-232

    112.  

  112. Hernandez, G. Lee and R.B. Maccioni (2008) “Tau phosphorylation by cdk5 and Fyn in response to amyloid peptide Aβ25 35: involvement of lipid rafts”. J. Alz. Dis. 16: 149-156

    113.  

  113. Sekler, J. Jimenez, L. Rojo, E Pastene, P. Fuentes, A. Slachevsky and R.B. Maccioni (2008) “Cognitive impairment and Alzheimer´s disease: links with oxidative stress and cholesterol metabolism”. J. Neuropsychiatric Diseases and Treatment 4, 715-722

    114.  

  114. Fernandez, L. Rojo, R.O. Kuljis and R.B. Maccioni (2008) “The damage signals hypothesis of Alzheimer´s disease pathogenesis”. J. Alz. Disease v.14: 329-333

    115.  

  115. Neumann, L. Rojo, L. Navarrete, G. Farias, P. Reyes and R.B. Maccioni (2008) “Insulin resistance and Alzheimer´s disease: Molecular links and clinical implications”. Curr. Alz. Res. 5: 438-447

    116.  

  116. B. Maccioni, L. Rojo, J. Fernandez and R. Kuljis (2009) “The role of neuroimmunomodulation in Alzheimer´s disease”. Ann New York Acad. Sci. 1153: 240-247

    117.  

  117. Hernandez, G. Lee and R.B. Maccioni (2009) “Tau phosphorylation by cdk5 and Fyn in response to amyloid peptide Aβ25 35: involvement of lipid rafts”. J. Alz. Dis. 16: 149-156

    118.  

  118. Utreras, R.B. Maccioni and C. Gonzalez (2009) “Cyclin-dependent kinase cdk5 activator p35 over-expression and amyloid beta synergism increase apoptosis in cultured neuronal cells” Neuroscience 161: 978-987

    119.  

  119. A. Zambrano, M.J. Marks, B. Cassels and R.B. Maccioni (2009) “In vivo effects of 3-Icytosine: Pharmacological and genetic analysis of hypothermia and evaluation of chronic treatment on nicotinic binding sites”. Neuropharmacology 57: 332-342

    120.  

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